| # | Ovr | Player/Week | YTD | Avg | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 |
|---|
| 1. | 1. | Brady, Tom NEP QB | 378 | 24 | 23 | 21 | 26 | 19 | 22 | 33 | 38 | 35 | 19 | B | 34 | 20 | 17 | 31 | 3 | 15 | 22 | | | | |
| 2. | 2. | Tomlinson, Ladainian SDC RB | 293 | 18 | 17 | 5 | 15 | 21 | 13 | 44 | B | 9 | 13 | 15 | 21 | 11 | 31 | 28 | 23 | 16 | 11 | | | | |
| 3. | 3. | Romo, Tony DAL QB | 283 | 18 | 34 | 18 | 19 | 31 | 8 | 13 | 13 | B | 22 | 23 | 25 | 13 | 26 | 21 | 3 | 13 | 1 | | | | |
| 4. | 4. | Moss, Randy NEP WR | 280 | 18 | 24 | 22 | 23 | 22 | 4 | 11 | 24 | 10 | 20 | B | 36 | 4 | 9 | 25 | 7 | 17 | 22 | | | | |
| 5. | 5. | Westbrook, Brian PHI RB | 269 | 18 | 12 | 15 | 40 | | B | 15 | 11 | 20 | 21 | 36 | 14 | 15 | 19 | 18 | 14 | 10 | 9 | | | | |
| 6. | 6. | Manning, Peyton IND QB | 267 | 17 | 23 | 14 | 14 | 25 | 16 | B | 18 | 18 | 15 | 10 | 4 | 20 | 25 | 25 | 13 | 24 | 3 | | | | |
| 7. | 7. | Roethlisberger, Ben PIT QB | 247 | 16 | 22 | 12 | 9 | 15 | 12 | B | 23 | 15 | 28 | 28 | 7 | 4 | 18 | 13 | 18 | 23 | | | | | |
| 8. | 8. | Brees, Drew NOS QB | 244 | 15 | 1 | 13 | -1 | B | 6 | 17 | 14 | 29 | 27 | 14 | 11 | 26 | 15 | 25 | 20 | 9 | 18 | | | | |
| 9. | 9. | Anderson, Derek CLE QB | 242 | 15 | 7 | 31 | 16 | 14 | 13 | 28 | B | 21 | 15 | 16 | 14 | 16 | 15 | 13 | 5 | 10 | 8 | | | | |
| 10. | 10. | Favre, Brett GBP QB | 237 | 15 | 4 | 21 | 26 | 19 | 12 | 3 | B | 21 | 18 | 26 | 20 | 25 | -2 | 16 | 13 | 2 | 13 | | | | |
| 11. | 11. | Hasselbeck, Matt SEA QB | 231 | 14 | 12 | 13 | 17 | 17 | 2 | 21 | 13 | B | 17 | 18 | 19 | 11 | 13 | 26 | 13 | 12 | 7 | | | | |
| 12. | 12. | Addai, Joseph IND RB | 222 | 15 | 19 | 14 | 20 | 20 | | B | 10 | 28 | 28 | 6 | 16 | 11 | 6 | 25 | 9 | 8 | 2 | | | | |
| 13. | 13. | Peterson, Adrian MIN RB | 222 | 16 | 22 | 11 | 18 | 11 | B | 40 | 11 | 7 | 46 | 5 | | | 24 | 0 | 20 | 4 | 3 | | | | |
| 14. | 14. | Palmer, Carson CIN QB | 221 | 14 | 15 | 37 | 13 | 9 | B | 14 | 11 | 12 | 16 | 10 | 13 | 21 | 7 | 3 | 14 | 4 | 22 | | | | |
| 15. | 15. | Owens, Terrell DAL WR | 218 | 15 | 20 | 15 | 14 | 3 | 2 | 12 | 16 | B | 23 | 24 | 41 | 12 | 21 | 2 | 3 | 10 | | | | | |
| 16. | 16. | Edwards, Braylon CLE WR | 212 | 13 | 2 | 26 | 14 | 15 | 11 | 24 | B | 23 | 6 | 7 | 6 | 11 | 20 | 12 | 6 | 17 | 12 | | | | |
| 17. | 17. | Portis, Clinton WAS RB | 210 | 13 | 15 | 12 | 15 | B | 6 | 6 | 17 | 7 | 25 | 15 | 3 | 5 | 12 | 11 | 18 | 21 | 22 | | | | |
| 18. | 18. | Lewis, Jamal CLE RB | 207 | 14 | 2 | 27 | 7 | 12 | 1 | | B | 6 | 33 | 1 | 18 | 20 | 14 | 24 | 17 | 13 | 12 | | | | |
| 19. | 19. | Warner, Kurt ARI QB | 199 | 14 | | | 18 | 7 | 15 | -2 | 13 | B | 2 | 18 | 16 | 21 | 12 | 15 | 17 | 26 | 21 | | | | |
| 20. | 20. | Cutler, Jay DEN QB | 198 | 12 | 15 | 10 | 10 | 12 | 7 | B | 21 | 12 | 0 | 11 | 16 | 19 | 2 | 27 | 15 | 4 | 17 | | | | |
| 21. | 21. | Wayne, Reggie IND WR | 198 | 12 | 21 | 7 | 8 | 9 | 12 | B | 13 | 22 | 6 | 20 | 7 | 12 | 21 | 10 | 6 | 18 | 6 | | | | |
| 22. | 22. | McNabb, Donovan PHI QB | 197 | 14 | 9 | 10 | 29 | 3 | B | 13 | 14 | 18 | 8 | 27 | -1 | | | 12 | 17 | 23 | 15 | | | | |
| 23. | 23. | Fitzgerald, Larry ARI WR | 188 | 13 | 2 | 8 | 6 | 10 | 19 | 7 | 9 | B | 9 | 19 | 15 | 27 | | 13 | 8 | 7 | 29 | | | | |
| 24. | 24. | Barber, Marion DAL RB | 187 | 12 | 14 | 20 | 23 | 7 | 6 | 5 | 15 | B | 16 | 3 | 4 | 17 | 8 | 28 | 3 | 18 | 0 | | | | |
| 25. | 25. | Chargers, San Diego SDC Def | 186 | 12 | 11 | 6 | 2 | 6 | 13 | 12 | B | 23 | 11 | 26 | 0 | 8 | 16 | 6 | 18 | 10 | 18 | | | | |
| 26. | 26. | Johnson, Chad CIN WR | 185 | 12 | 15 | 32 | 13 | 5 | B | 8 | 11 | 5 | 4 | 7 | 6 | 28 | 8 | 6 | 7 | 5 | 25 | | | | |
| 27. | 27. | Houshmandzadeh, T.J. CIN WR | 179 | 11 | 11 | 18 | 18 | 16 | B | 26 | 10 | 14 | 10 | 4 | 14 | 6 | 4 | 5 | 6 | 8 | 9 | | | | |
| 28. | 28. | Colston, Marques NOS WR | 176 | 11 | 4 | 13 | 6 | B | 3 | 6 | 4 | 24 | 15 | 12 | 11 | 15 | 3 | 21 | 17 | 1 | 21 | | | | |
| 29. | 29. | Garrard, David JAC QB | 175 | 15 | 14 | 16 | 13 | B | 12 | 18 | 2 | | | | 15 | 15 | 16 | 17 | 17 | 20 | | | | | |
| 30. | 30. | Kitna, Jon DET QB | 175 | 11 | 20 | 12 | 19 | 15 | 0 | B | 5 | 10 | 18 | 11 | 13 | 10 | 12 | 9 | 10 | 2 | 9 | | | | |